The name Al-Maidicleofenac Sodium 12.5 mg suppositories belong to the analgesics, antipyretics, and anti-inflammatory drugs. The mechanism of action of Diclofenac: Diclofenac belongs to a group of drugs called non-steroidal anti-inflammatory drugs (NSAIDs), which work by inhibiting the cyclooxygenase enzymes COX-1 and COX-2, thereby inhibiting prostaglandin formation. It also prevents the aggregation/activation of neutrophil cells, inhibits the movement of cells causing inflammation, reduces the level of cytokines that cause inflammation, and alters the activity of lymphocyte cells. Medical uses of Diclogesic 12.5 mg suppositories: Relieve pain, reduce swelling, and ease inflammation in cases affecting joints, muscles, and tendons. Fever and high temperatures treatment. Pain and inflammation associated with dental surgery and minor surgery. Osteoarthritis, rheumatoid arthritis, osteoporosis, acute gout, ankylosing spondylitis. Back pain. Sprains, sports injuries, dislocations, fractures. Tendon conditions such as tendinitis. How to use Diclogesic 12.5 mg suppositories: Suppositories are designed to be inserted into the rectum. Do not take them orally. How to use: Lie on one side with your knees raised toward your chest. Gently push the pointed end of the suppository into the rectum using your finger. Push the suppository inside as far as possible. Lower your legs, and if possible, stay still for a few minutes. If you feel the need to expel the suppository, try to resist by lying still with your buttocks pressed together. It is important to keep the suppository in the rectum to allow it to melt and absorb the medication. Pushing the suppository high into the rectum with your finger will help reduce this feeling. Wash your hands. Consult your doctor or pharmacist if your child is between 1-3 years old before use. For children over one year, the dose is 1-3 mg/kg/day divided into two or three doses. Doses may be adjusted in special cases, so always follow your doctor’s or pharmacist’s instructions. If you take more than the recommended dose, contact your doctor or go to the hospital immediately. If you forget a dose, take it as soon as you remember unless it’s time for your next dose. Do not take a double dose (two doses at the same time) to make up for the missed dose. Side effects of Diclogesic 12.5 mg suppositories: Stomach pain, burning, nausea, vomiting, diarrhea, dyspepsia, loss of appetite. Headache, dizziness. Rash or spots. Elevated liver enzyme levels in the blood. Irritation and inflammation at the site of suppository insertion. Using Diclogesic 12.5 mg suppositories during pregnancy and breastfeeding: If you are pregnant or breastfeeding, think you are pregnant, or planning to have a baby, ask your doctor or pharmacist for advice before taking this medication. Not preferred, especially during the first three months. Helpful tips for pain relief: Gentle massage of the painful area. Relaxation techniques. Some physical therapy methods. Gel compresses. Warnings and precautions while using Diclogesic 12.5 mg suppositories: Suppositories may sometimes cause itching or burning in the rectal passage. Stop using the medication and inform your doctor immediately if you notice: Sudden chest pain (signs of a heart attack or myocardial infarction). Shortness of breath, difficulty breathing when lying down, swelling of the feet or legs (signs of heart failure). Sudden weakness or numbness in the face, arm, or leg, especially on one side of the body. Sudden loss or disturbance of vision. Sudden difficulty speaking or understanding speech. A sudden headache similar to migraine occurring for the first time with or without disturbed vision, which can be an early sign of a stroke. Stomach pain, indigestion, burning, nausea, or vomiting (feeling of nausea). Any sign of stomach or intestinal bleeding, such as blood in vomit or black stool. Allergic reactions that may include rash, itching, bruising, red painful areas, peeling, or ulcers on the skin. Tell your doctor or pharmacist if you are taking any of the following: Medications for diabetes. Anticoagulants (blood-thinning pills like warfarin). Diuretics (water pills). Lithium (used for some mental health issues). Methotrexate (for some inflammatory diseases and certain cancers). Cyclosporine and Tacrolimus (used for some inflammatory diseases and post-transplant). Trimethoprim (used to prevent or treat urinary tract infections). Quinolone antibiotics (for infections). Any NSAIDs or COX-2 inhibitors (such as aspirin or ibuprofen). Cardiac glycosides (e.g., digoxin), used for heart problems. Medications known as SSRIs used for depression. Oral stimulants (anti-inflammatory drugs). Medications for heart disease or high blood pressure, such as beta-blockers or ACE inhibitors. Furiconazole (used for fungal infections). Phenytoin (used for seizures). Cholestyramine/Colestipol (used to lower cholesterol). How to store Diclogesic 12.5 mg suppositories: Store at temperatures below 25°C. Keep this medication out of sight and reach of children. Store in the original container to protect from moisture. Do not use this medication after the expiration date printed on the box/blister/label. The expiration date indicates the last day of the month.